Dr. Fertig runs an NCI funded hybrid computational and experimental lab in the systems biology of cancer and therapeutic response. Her wet lab develops time course models of therapeutic resistance and performs single cell technology development. Her computational methods blend mathematical modeling and artificial intelligence to determine the biomarkers and molecular mechanisms of therapeutic resistance from multi-platform genomics data. These techniques have broad applicability beyond her resistance models, including notably to the analysis of clinical biospecimens, developmental biology, and neuroscience.
Dr. Fertig is an Associate Professor of Oncology and Assistant Director of the Research Program in Quantitative Sciences and Associate Director of the Convergence Institute at Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center, with secondary appointments in Biomedical Engineering and Applied Mathematics and Statistics, affiliations in the Institute of Computational Medicine, Center for Computational Genomics, Machine Learning, Mathematical Institute for Data Science, and the Center for Computational Biology. Prior to entering the field of computational cancer biology, Dr Fertig was a NASA research fellow in numerical weather prediction. Dr. Fertig's research is featured in over eighty peer-reviewed publications, R/Bioconductor packages, and competitive funding portfolio as PI and co-I. Notably, she led the team that won the HPN-DREAM8 algorithm to predict phospho-proteomic trajectories from therapeutic response in cancer cells. She serves on the editorial boards of the pre-eminent computational biology journals PLoS Computational Biology, Cell Systems, ImmunoInformatics, and as a study section member for the NCI Systems Biology, NCI Informatics Technology for Cancer Research, and Israel Cancer Research Fund Study Sections.